(HealthDay News

SATURDAY, Oct. 24

Gene therapy can improve the vision of people with a severe form of genetically inherited retinal degeneration called Leber congenital amaurosis (LCA), a new study shows.
People with LCA, which is caused by mutations in any of least 13 genes, have severe vision loss and abnormal eye movements in early infancy and during early childhood. Most people with the disease are blind by their 30s or 40s. There is no cure, according to background information provided in a news release.
The new phase I trial included 12 patients, aged 8 to 44 years, who were injected in one eye with genetic material meant to correct LCA. The gene therapy led to at least a 100-fold increase in pupillary light response (constriction of the pupil when it's exposed to light) in the participants. An 8-year-old patient developed nearly the same level of light sensitivity as a person with normal vision, the study authors reported.
In general, the greatest improvements were seen in children aged 8 to 11, all of whom gained ambulatory vision -- being able to see well enough to walk unaided.
"All 12 patients given gene therapy in one eye showed improvement in retinal function. The effect was stable during follow-up. The results support our hypothesis that the response to subretinal gene therapy depends on the extent of retinal degeneration and, therefore, the age of the patient," wrote Dr. Jean Bennett, of the University of Pennsylvania School of Medicine in Philadelphia, and colleagues.
"The most noteworthy result was the ability of children to navigate an obstacle course independently and accurately, even in dim light," the study authors wrote. "The visual recovery noted in the children confirms the hypothesis that efficacy will be improved if treatment is applied before retinal degeneration has progressed. Assessment of whether the treatment alters the natural progression of the retinal degeneration will be possible in follow-up studies," they added.
"The success of this gene therapy study in children provides the foundation for gene therapy approaches to the treatment of other forms of LCA and of additional early onset retinal diseases," the researchers concluded.
The study is published in the Oct. 24 online edition and in an upcoming print issue of The Lancet.

Homeowners insurance

Homeowners insurance, or home insurance, compensates you for losses to your home and your possessions inside it, so purchasing a homeowners policy provides added security for your investment. Home insurance also protects you if you're legally liable for someone's injuries on your property, as well as from financial losses caused by storms, fire, theft and other events outlined in your policy.
Why buy condo insurance?
Home insurance isn't your only option when it comes to protecting your belongings. When you own a condominium, you — not your condo association — are responsible for what's inside your condo. That's why having a personal condo insurance policy is important.
Why buy renters insurance?
Renters insurance protects you in situations that everyone can face: fire, theft, water damage and other unforeseen circumstances — situations your apartment owner's policy doesn't cover.

Homeowners insurance, or home insurance, compensates you for losses to your home and your possessions inside it, so purchasing a homeowners policy provides added security for your investment. Home insurance also protects you if you're legally liable for someone's injuries on your property, as well as from financial losses caused by storms, fire, theft and other events outlined in your policy.
Why buy condo insurance?
Home insurance isn't your only option when it comes to protecting your belongings. When you own a condominium, you — not your condo association — are responsible for what's inside your condo. That's why having a personal condo insurance policy is important.
Why buy renters insurance?
Renters insurance protects you in situations that everyone can face: fire, theft, water damage and other unforeseen circumstances — situations your apartment owner's policy doesn't cover.

Debate grows over US ruling on marijuana

WASHINGTON - Advocates of medical marijuana praised a Justice Department decision yesterday not to target cannabis-smoking patients or their sanctioned suppliers in the 14 states that allow marijuana use, but critics called it a retreat in the war on drugs.

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Federal prosecutors were told about the new policy in a legal memo issued by the department yesterday. Cannabis-smoking patients or their sanctioned suppliers should not be targeted for federal prosecution in the 14 states that allow medicinal marijuana, prosecutors were told.

The guidelines make it clear, however, that federal agents will go after people whose marijuana distribution goes beyond what is permitted under state law or use medicinal marijuana as a cover for other crimes.

The memo advises prosecutors they “should not focus federal resources in your states on individuals whose actions are in clear and unambiguous compliance with existing state laws providing for the medical use of marijuana.’’

The policy is a shift from the Bush administration, which insisted it would continue to enforce federal anti-marijuana laws regardless of state codes.

“It will not be a priority to use federal resources to prosecute patients with serious illnesses or their caregivers who are complying with state laws on medical marijuana, but we will not tolerate drug traffickers who hide behind claims of compliance with state law to mask activities that are clearly illegal,’’ Attorney General Eric Holder said.

“This is a major step forward,’’ said Bruce Mirken, communications director for the Marijuana Policy Project, a group that promotes the decriminalization of marijuana use. “This change in policy moves the federal government dramatically toward respecting scientific and practical reality.’’

Critics of the change, including some lawmakers, said it was a setback in the fight against Mexican drug cartels.

“We cannot hope to eradicate the drug trade if we do not first address the cash cow for most drug trafficking organizations - marijuana,’’ said Representative Lamar Smith of Texas, the top Republican on the House Judiciary Committee.

Justice Department officials say the new policy is intended to lay out prosecutorial priorities to US attorneys in the states that allow medicinal marijuana. It notes that marijuana sales in the United States are the largest source of money for violent Mexican drug cartels, but adds that federal law enforcement agencies have limited resources.

By the government’s count, 14 states allow some use of marijuana for medical purposes: Alaska, California, Colorado, Hawaii, Maine, Maryland, Michigan, Montana, Nevada, New Mexico, Oregon, Rhode Island, Vermont, and Washington. Some medicinal marijuana advocates say Maryland shouldn’t be included in that group, because the law there allows only reduced penalties for medicinal marijuana usage.

California stands out among those for the widespread presence of dispensaries - businesses that sell marijuana and even advertise their services.

Colorado also has several dispensaries, and Rhode Island and New Mexico are in the process of licensing providers, according to the Marijuana Policy Project.

Los Angeles County District Attorney Steve Cooley said last week that he wants to close dispensaries that sell marijuana for profit. Cooley’s plan is the latest salvo in a prolonged conflict in California over whether medicinal marijuana is truly having its intended effect or is being abused by the larger population.

Until recently, raids on clinics typically led to federal prosecutions, but Cooley’s remarks and similar ones from Attorney General Jerry Brown signal a new approach to clear the confusion left by Proposition 215, the 1996 state ballot measure that allowed sick people with referrals from doctors and an identification card to smoke marijuana.

Advocates say marijuana is effective in treating chronic pain and nausea, among other ailments.

Holder said in March that he wanted federal law enforcement officials to pursue those who violate both federal and state law, but it has not been clear how that goal would be put into practice.

The memo written by Deputy Attorney General David Ogden emphasizes that prosecutors have wide discretion in choosing which cases to pursue, and says it is not a good use of federal manpower to prosecute those who are without a doubt in compliance with state law.

Gay rights activists press cause in D.C.

Thousands of supporters of gay rights marched Sunday from the White House to the Capitol, demanding that President Obama keep his promises to allow gays to serve openly in the military and work to end discrimination against gays.

Rainbow flags and homemade signs dotted the crowds filling Pennsylvania Avenue in front of the White House as people chanted "Hey, Obama, let mama marry mama" and "We're out, we're proud, we won't back down." Many children were also among the protesters. A few counterprotesters had also joined the crowd, which stretched several blocks by the afternoon.

Jason Yanowitz, a 37-year-old computer programmer from Chicago, held his 5-year-old daughter, Amira, on his shoulders. His partner, Annie, had their 2-year-old son, Isiah, in a stroller. Mr. Yanowitz said more straight people were turning out to show their support for gay rights.

"If somebody doesn't have equal rights, then none of us are free," he said.

"For all I know, she's gay or he's gay," he added, pointing to his children.



Some participants in the National Equality March woke up energized by Mr. Obama's blunt pledge to end the ban on gays serving openly in the military during a speech to the nation's largest gay rights group Saturday night.

The chairman of the Senate Armed Services Committee said Sunday that Congress would need to muster the resolve to change the "don't ask, don't tell" policy - a change that the military may be ready for.

"I think it has to be done in the right way, which is to get a buy-in from the military, which I think is now possible," said Sen. Carl Levin, Michigan Democrat.

Mr. Obama's political energies have been focused on two wars, the economic crisis and health care reform, though he pledged "unwavering" commitment even as he wrestled with those problems.

Want to lose weight

Want to lose weight as you chow down? Your wish is granted! (I promise, this is no fairy tale.) Your supermarket is filled with foods that studies show have lipid-melting powers to help melt fat and keep you slim. Stock up on these fat-fighting super bites, and you'll be trimmer even as you indulge. Read on to discover the eight foods that deserve a permanent spot in your fridge—and in your diet!

Almonds These yummy nuts are high in alpha-linolenic acid, which can accelerate your metabolism of fats. In fact, dieters who ate 3 ounces of almonds daily slashed their weight and body-mass index by 18 percent, while those who skipped the nuts reduced both numbers less— just 11 percent—a study in the International Journal of Obesity revealed. Chomp almonds à la carte (limit yourself to 12 per serving to keep calories in check). I get a pack at Starbucks and nibble throughout my day. Or sprinkle them into a recipe such as Black Bean–Almond Pesto Chicken. Go nuts!

Berries I tell my daughter, "These are nature's candy!" Turns out they're also your body's best friends. Strawberries, raspberries and other vitamin C–spiked fruit can supercharge your workout, helping you burn up to 30 percent more fat, research from Arizona State University at Mesa has found. If they're not in season, buy the little gems frozen in a bulk-sized bag so you'll always have them on hand to whip up a Berry Bliss Smoothie or Strawberry-Sunflower Pops, regardless of whether berries are in season.

Cinnamon Adding 1/4 teaspoon to your plate may prevent an insulin spike—an uptick that tells your body to store fat. Sprinkle it on your morning cereal or coffee or on your yogurt in the A.M., or savor it in Apple-Cinnamon-Raisin Oatmeal.

Mustard It's heaven on a soft pretzel, but mustard may also be a weight loss wonder. Turmeric, the spice that gives mustard its color, may slow the growth of fat tissues, a study in the journal Endocrinology finds. Use it on sandwiches instead of mayo, or sprinkle turmeric on cauliflower pre-roasting to give it a kick. Try it on tuna salad—I promise it adds zest.

Oranges This citrus fruit, which contains fat-blasting compounds known as flavones, deserves to be your main squeeze. Women who ate the most flavones had a much lower increase in body fat over a 14-year period, a study in The American Journal of Clinical Nutrition notes. Eat oranges sliced or swig fresh OJ (including pulp!) to get the best benefit from the fruit.

Soybeans Reason to toss a half cup on your salad? Soybeans are rich in choline, a compound that blocks the absorption of fat and breaks down fatty deposits. Oh, and they're addictively delish! But if breast cancer runs in your family, experts suggest you should talk to your doc before adding soy to your diet.

Sweet potatoes The colorful spuds' high-fiber content means they keep your insulin steadier than their white sisters, which means less fat packed on your hips, research finds. Top a small baked tater with lowfat cottage cheese for a tempting side dish, or whip up Miso Soup With Sweet Potato Dumplings.

Swiss cheese Calcium-rich foods reduce fat-producing enzymes and increase fat breakdown, and Swiss has more calcium than many of its cheesy peers. Choose the reduced-fat variety, such as Sargento. Slip it into your sandwich, put it on top of high-fiber crackers or use it for a healthier grilled cheese. Yum!

For other tricks to eating your way to your healthy, happy weight, load up on these 20 slimming superfoods at Self.com.

Darchula Nepal